How do we determine whether antidepressants are useful or not? – Authors' reply

How can we know whether antidepressants increase suicide risk?

In this issue of the Journal, Gibbons and colleagues use pharmacy records and mortality data to examine the association between rates of antidepressant use and rates of suicide death in children and younger adolescents. They find that U.S. counties with higher rates of SSRI antidepressant use had lower rates of suicide death, and that this relationship persisted after accounting for potential c...

How do we determine atrial arrangement?

and his colleagues present a detailed and careful analysis of the arrangement of the heart and thoraco-abdominal organs in a large series of over one thousand autopsied patients.1 Their findings bear directly upon the controversy in which I was recently involved at the 3rd World Congress of Pediatric Cardiology and Cardiac Surgery. The controversy sessions took place on the last day of the Symp...

The Authors’ Reply

The Authors’ Reply

To E or not to E--how do we tell?

Clinical disease resulting from atherosclerosis continues to cause extensive mortality and morbidity and uses an exorbitant amount of the financial resources available for health care. Atherosclerosis is a complex, multifactorial, and chronic disease influenced by a wide variety of genetic, environmental, and behavioral activities. However, it is at last widely recognized that among the known r...